Kyle Shanahan said Christian McCaffrey suffered a potentially season-ending PCL injury.

#49ers QB Brock Purdy, who was questionable despite practicing fully on Friday, is slated to go today, coach Kyle Shanahan said this week.

Awful: A #Bills fan tried throwing a snowball at Jake Moody's field goal to make him miss. Watch closely 🤦‍♂️ pic.x.com/OgdUQUIhb5

Who would have thought that the great Kyle Juszczyk would put the final nail in the 49ers' coffin this season? Not me. I'm a big fan of his.

Fred Warner, about to play his 10th straight game on a broken ankle, warms up in shorts and without sleeves. Football guy pic.x.com/NmMMRZsx1a

#49ers players to miss time this season: Christian McCaffrey, Brock Purdy, Nick Bosa, Trent Williams, Deebo Samuel, George Kittle, Brandon Aiyuk, Jauan Jennings, Ricky Pearsall, Javon Hargrave, Charvarius Ward, Deommodore Lenoir, Elijah Mitchell, Talanoa Hufanga, Dre Greenlaw, Jake Moody, and others. It's utterly insane.

@MySportsUpdate: Just in: The #49ers are worried RB Christian McCaffrey suffered a potentially season-ending PCL injury. https://t.co/925LQJ5qdw

George Kittle has one target tonight. Someone tell the genius to get him the ball.

We all underestimated how good Nick Bosa is. Without him, the bottom has absolutely fallen out for the 49ers defense

So why the **** did Brandon Allen start last week?

@mattbarrows: QB Brandon Allen is among the 49ers' inactive today. That means Josh Dobbs in the top backup for today's game.

Ben Bartch just helped open up a HUGE hole for CMC

Charvarius Ward committed the penalty that jumpstarted Buffalo's drive and then he was unable to contain Ray Davis to the perimeter on the play that finished it

Ben Bartch is slated to get his first start with the 49ers at left guard, replacing Aaron Banks (concussion)

That Deebo Samuel return to open the second half was not called back by a phantom penalty

Joshua Dobbs needs to play in the second half.

I have a feeling Jordan Mason will get a big workload tonight.

#49ers DT Kevin Givens just emerged from the blue tent and is headed to the locker room. Givens just returned from groin injury tonight.

#49ers finally in the end zone as Isaac Guerendo takes it 15 yards off left end for the score. Trims Buffalo lead to 28-10 with 2:54 left in third quarter.

#49ers LB Fred Warner is not yet back on the field or from the locker room to open this Bills' possession. Current LBs (nickel): De'Vondre Campbell/Dee Winters/Jalen Graham

It's Nick McCloud in the slot as #49ers go into nickel on second down.